Jump to main content
Jump to site search


Nickel(II)-catalyzed enantioselective α-alkylation of β-ketoamides with phenyliodonium ylide via a radical process

Author affiliations

Abstract

Chiral Lewis acid-promoted enantioselective α-alkylation of β-ketoamides with phenyliodonium ylide was developed. In the presence of a chiral N,N′-dioxide/Ni(II) complex, the corresponding 1,4-dicarbonyl compounds were obtained with good results (up to 91% yield and 97% ee). Control experiments and EPR studies supported a radical process.

Graphical abstract: Nickel(ii)-catalyzed enantioselective α-alkylation of β-ketoamides with phenyliodonium ylide via a radical process

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Sep 2018, accepted on 05 Oct 2018 and first published on 05 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07140C
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    Nickel(II)-catalyzed enantioselective α-alkylation of β-ketoamides with phenyliodonium ylide via a radical process

    J. Guo, X. Liu, C. He, F. Tan, S. Dong and X. Feng, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07140C

Search articles by author

Spotlight

Advertisements