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Enhancing intracellular microRNA imaging: a new strategy combining double-channel exciting single colour fluorescence with the target cycling amplification reaction

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Abstract

A microRNA (miRNA) fluorescence (FL) nanoprobe based on PDA-UCNPs@FAM-LLD@AuNPs was developed, which exhibited an enhanced signal for imaging intracellular miRNA by combining double-channel exciting single colour FL (DCESCF) with the target cycling amplification reaction. Through this strategy, normal cells and cancer cells could be successfully discriminated.

Graphical abstract: Enhancing intracellular microRNA imaging: a new strategy combining double-channel exciting single colour fluorescence with the target cycling amplification reaction

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Publication details

The article was received on 01 Sep 2018, accepted on 24 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07112H
Citation: Chem. Commun., 2018, Advance Article
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    Enhancing intracellular microRNA imaging: a new strategy combining double-channel exciting single colour fluorescence with the target cycling amplification reaction

    K. Zhang, S. Song, L. Yang, Q. Min, X. Wu and J. Zhu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07112H

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