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Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy

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Abstract

In this work, we decorated the surface of MSNs by a one-pot Passerini reaction using near-infrared fluorescence BODIPY and poly(ethylene glycol) with an aldehyde group (PEG-CHO) for the first time. Doxorubicin (Dox) was loaded to demonstrate the reduction response. The formed MSNs neatly integrate chemotherapy, photothermal therapy and near-infrared fluorescence (NIRF) imaging.

Graphical abstract: Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy

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Publication details

The article was received on 03 Sep 2018, accepted on 22 Sep 2018 and first published on 25 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07106C
Citation: Chem. Commun., 2018, Advance Article
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    Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy

    Y. Zhu, W. Lin, X. Wang, W. Zhang, L. Chen and Z. Xie, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07106C

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