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Issue 92, 2018
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Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

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Abstract

Multicomponent reactions (MCRs) are robust tools for the rapid synthesis of complex, small molecule libraries for use in drug discovery and development. By utilizing MCR chemistry, we developed a protocol to functionalize the C-3 position of imidazo[1,2-a]pyridine through a three component, decarboxylation reaction involving imidazo[1,2-a]pyridine, glyoxalic acid, and boronic acid.

Graphical abstract: Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

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Publication details

The article was received on 31 Aug 2018, accepted on 22 Oct 2018 and first published on 23 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07063F
Citation: Chem. Commun., 2018,54, 12954-12957
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    Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

    N. Gunaganti, A. Kharbanda, N. R. Lakkaniga, L. Zhang, R. Cooper, H. Li and B. Frett, Chem. Commun., 2018, 54, 12954
    DOI: 10.1039/C8CC07063F

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