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Iron-catalyzed synthesis of cyclopropanes by in situ generation and decomposition of electronically diversified diazo compounds

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Abstract

The modular synthesis of a variety of trans 1,2-disubstituted cyclopropanes in a safe and user-friendly one-pot iron-catalyzed cyclopropanation reaction is described. Easily synthesized N-nosylhydrazones are used as diazo precursors, allowing the in situ generation of electron-rich diazo compounds under mild reaction conditions and their direct participation in the cyclopropanation reaction.

Graphical abstract: Iron-catalyzed synthesis of cyclopropanes by in situ generation and decomposition of electronically diversified diazo compounds

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Publication details

The article was received on 31 Aug 2018, accepted on 26 Oct 2018 and first published on 30 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07060A
Citation: Chem. Commun., 2018, Advance Article
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    Iron-catalyzed synthesis of cyclopropanes by in situ generation and decomposition of electronically diversified diazo compounds

    E. M. D. Allouche, A. Al-Saleh and A. B. Charette, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07060A

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