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Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

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Abstract

A supramolecular catiomer with a metal–organic framework (MOF) motif was developed to manufacture messenger RNA (mRNA) assemblies. In contrast to the linear catiomer, the dendritic MOF catiomer appeared to markedly improve the colloidal stability of the mRNA assemblies, particularly affording substantial protection to the mRNA payloads from enzymatic degradation, eventually conducing to appreciable mRNA transfection activities at the targeted cells.

Graphical abstract: Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

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Publication details

The article was received on 30 Aug 2018, accepted on 14 Sep 2018 and first published on 14 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07047D
Citation: Chem. Commun., 2018, Advance Article
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    Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

    P. Sun, Z. Li, J. Wang, H. Gao, X. Yang, S. Wu, D. Liu and Q. Chen, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07047D

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