Issue 80, 2018

Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

Abstract

A supramolecular catiomer with a metal–organic framework (MOF) motif was developed to manufacture messenger RNA (mRNA) assemblies. In contrast to the linear catiomer, the dendritic MOF catiomer appeared to markedly improve the colloidal stability of the mRNA assemblies, particularly affording substantial protection to the mRNA payloads from enzymatic degradation, eventually conducing to appreciable mRNA transfection activities at the targeted cells.

Graphical abstract: Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

Supplementary files

Article information

Article type
Communication
Submitted
30 Aug 2018
Accepted
14 Sep 2018
First published
14 Sep 2018

Chem. Commun., 2018,54, 11304-11307

Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform

P. Sun, Z. Li, J. Wang, H. Gao, X. Yang, S. Wu, D. Liu and Q. Chen, Chem. Commun., 2018, 54, 11304 DOI: 10.1039/C8CC07047D

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