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Enzyme-free amplified DNA assay: five orders of linearity provided by metal stable isotope detection

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Abstract

For the quantification of mutated genes at greatly varied concentrations in body fluids, nucleic acid amplification strategies are often challenged by limited dynamic linear ranges. The proposed metal stable isotope detection strategy demonstrates five orders of linear range and a lower attomol detection limit, showing promising potential in clinical diagnosis.

Graphical abstract: Enzyme-free amplified DNA assay: five orders of linearity provided by metal stable isotope detection

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Publication details

The article was received on 30 Aug 2018, accepted on 25 Oct 2018 and first published on 26 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07036A
Citation: Chem. Commun., 2018, Advance Article
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    Enzyme-free amplified DNA assay: five orders of linearity provided by metal stable isotope detection

    Y. Liu, Y. Ding, Y. Gao, R. Liu, X. Hu and Y. Lv, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC07036A

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