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Issue 80, 2018
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Templated synthesis of spherical RNA nanoparticles with gene silencing activity

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Abstract

RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solution and show gene silencing activity.

Graphical abstract: Templated synthesis of spherical RNA nanoparticles with gene silencing activity

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Publication details

The article was received on 28 Aug 2018, accepted on 13 Sep 2018 and first published on 13 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06994H
Citation: Chem. Commun., 2018,54, 11296-11299
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    Templated synthesis of spherical RNA nanoparticles with gene silencing activity

    M. D. Dore, J. J. Fakhoury, A. Lacroix and H. F. Sleiman, Chem. Commun., 2018, 54, 11296
    DOI: 10.1039/C8CC06994H

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