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Issue 80, 2018
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Templated synthesis of spherical RNA nanoparticles with gene silencing activity

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Abstract

RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solution and show gene silencing activity.

Graphical abstract: Templated synthesis of spherical RNA nanoparticles with gene silencing activity

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Article information


Submitted
28 Aug 2018
Accepted
13 Sep 2018
First published
13 Sep 2018

Chem. Commun., 2018,54, 11296-11299
Article type
Communication

Templated synthesis of spherical RNA nanoparticles with gene silencing activity

M. D. Dore, J. J. Fakhoury, A. Lacroix and H. F. Sleiman, Chem. Commun., 2018, 54, 11296
DOI: 10.1039/C8CC06994H

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