RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solution and show gene silencing activity.
M. D. Dore, J. J. Fakhoury, A. Lacroix and H. F. Sleiman, Chem. Commun., 2018, 54, 11296 DOI: 10.1039/C8CC06994H
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