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Lewis acid-catalyzed Friedel–Crafts reactions toward highly versatile, α-quaternary oxime ethers

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Abstract

The synthesis of all-carbon-substituted, quaternary stereocenters through Lewis acid-catalyzed Friedel–Crafts alkylation of cyclic and acyclic 2-hydroxy oxime ethers proceeds under mild reaction conditions and with high yields. Moreover, the oxime ether moiety can be easily manipulated into various functional groups through subsequent modifications.

Graphical abstract: Lewis acid-catalyzed Friedel–Crafts reactions toward highly versatile, α-quaternary oxime ethers

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Publication details

The article was received on 22 Aug 2018, accepted on 10 Sep 2018 and first published on 11 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06823B
Citation: Chem. Commun., 2018, Advance Article
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    Lewis acid-catalyzed Friedel–Crafts reactions toward highly versatile, α-quaternary oxime ethers

    M. Schlegel and C. Schneider, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06823B

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