Marcel Schlegel and Christoph Schneider
Chem. Commun., 2018,54, 11124-11127
DOI:
10.1039/C8CC06823B,
Communication
The synthesis of all-carbon-substituted, quaternary stereocenters through Lewis acid-catalyzed Friedel–Crafts alkylation of cyclic and acyclic 2-hydroxy oxime ethers proceeds under mild reaction conditions and with high yields. Moreover, the oxime ether moiety can be easily manipulated into various functional groups through subsequent modifications.
