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CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

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Abstract

A new DNA binding small molecule, NCD-CC is reported. NCD-CC has a NCD domain, which recognizes the G–G mismatch in a CGG/CGG triad, and a cysteinylcystein (CC) moiety. Dimerization of NCD-CC through intermolecular disulfide bond formation was accelerated in the presence of CGG repeat DNA.

Graphical abstract: CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

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Publication details

The article was received on 20 Aug 2018, accepted on 25 Sep 2018 and first published on 25 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06757K
Citation: Chem. Commun., 2018, Advance Article
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    CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation

    T. Yamada, S. Miki, L. Ni and K. Nakatani, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06757K

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