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Issue 88, 2018
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Cu(I)/{Nb6O19} catalyzed N-acylation of arylacetic acids with amines under aerobic conditions

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Abstract

The method described herein is a general, efficient and green approach to synthesize α-ketoamides from arylacetic acids and amines. Employing a simple copper(I)/{Nb6O19} catalyst system, the reaction offers a facile process to give functionalized α-ketoamides from readily available arylacetic acids under aerobic conditions. The merit of this new strategy is that it expands the syntheses of α-ketoamides from stable, inexpensive and widely available acylation reagents such as arylacetic acids in one step.

Graphical abstract: Cu(i)/{Nb6O19} catalyzed N-acylation of arylacetic acids with amines under aerobic conditions

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Publication details

The article was received on 18 Aug 2018, accepted on 10 Oct 2018 and first published on 10 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06721J
Citation: Chem. Commun., 2018,54, 12471-12474
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    Cu(I)/{Nb6O19} catalyzed N-acylation of arylacetic acids with amines under aerobic conditions

    P. Li, Z. Wang, H. Fu, Q. Dai and C. Hu, Chem. Commun., 2018, 54, 12471
    DOI: 10.1039/C8CC06721J

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