Jump to main content
Jump to site search


Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

Author affiliations

Abstract

Numerous excellent fluorogenic probes for NO detection based on NO-mediated reactions have been developed. However, some of them still suffer from limitations such as low selectivity, slow response, and a short excitation wavelength (<500 nm). Herein, a novel two-photon fluorogenic probe (XNO1) based on a Schiff base derivative has been reported for the first time. This new mechanism with a Schiff base structure as the specific response moiety towards NO endows the probe with fast responsibility, high selectivity and pH-independent properties. Furthermore, XNO1 has been demonstrated to be lysosome-targeted and to successfully monitor exogenous/endogenous NO in living cells and zebrafishes with one- and two-photon fluorescence imaging.

Graphical abstract: Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Aug 2018, accepted on 13 Oct 2018 and first published on 16 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06698A
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

    C. Xu, C. Xin, C. Yu, M. Wu, J. Xu, W. Qin, Y. Ding, X. Wang, L. Li and W. Huang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06698A

Search articles by author

Spotlight

Advertisements