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Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer

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Abstract

We report in this communication the first preparation of triblock copolymer-based biocleavable shell cross-linked (SCL) hybrid micelles using a reducible silica monomer that integrates a polymerizable methacrylate structure and in situ cross-linkers of silica precursors via a disulfide bond. The monomer developed herein offers a highly straightforward and robust strategy toward bioreducible silica-based hybrid nanoparticles for controlled drug release.

Graphical abstract: Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer

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Publication details

The article was received on 16 Aug 2018, accepted on 12 Oct 2018 and first published on 12 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06685J
Citation: Chem. Commun., 2018, Advance Article
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    Fabrication of biocleavable shell cross-linked hybrid micelles for controlled drug release using a reducible silica monomer

    X. Zhang, X. Zhang, L. Sun, F. Liu, M. Wang, J. Peng, Y. Wang, L. Ma, B. Wang and H. Wei, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06685J

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