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Fabrication of Biocleavable Shell Cross-linked Hybrid Micelles for Controlled Drug Release Using a Reducible Silica Monomer

Abstract

We reported in this communication the first preparation of a triblock copolymer-based biocleavable shell cross-linked (SCL) hybrid micelle using a reducible silica monomer that integrates a polymerizable methacrylate structure and in-situ cross-linkers of silica precursors via a disulfide bond. The monomer developed herein offers a highly straightforward and robust strategy toward bioreducible silica-based hybrid nanoparticles for controlled drug release.

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Publication details

The article was received on 16 Aug 2018, accepted on 12 Oct 2018 and first published on 12 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06685J
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Fabrication of Biocleavable Shell Cross-linked Hybrid Micelles for Controlled Drug Release Using a Reducible Silica Monomer

    X. Zhang, X. Zhang, L. Sun, F. Liu, M. Wang, J. Peng, Y. Wang, L. Ma, B. Wang and H. Wei, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC06685J

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