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Issue 77, 2018
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The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids

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Abstract

The Strecker reaction is broadly used for the preparation of α-amino acids. However, control of enantioselectivity remains challenging. We here couple the Strecker reaction to Viedma ripening for the absolute asymmetric synthesis of highly sterically hindered α-amino acids. As proof-of-principle, the enantiomerically pure α-amino acids tert-leucine and α-(1-adamantyl)glycine were obtained.

Graphical abstract: The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids

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Article information


Submitted
15 Aug 2018
Accepted
24 Aug 2018
First published
24 Aug 2018

Chem. Commun., 2018,54, 10832-10834
Article type
Communication

The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids

I. Baglai, M. Leeman, K. Wurst, B. Kaptein, R. M. Kellogg and W. L. Noorduin, Chem. Commun., 2018, 54, 10832
DOI: 10.1039/C8CC06658B

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