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Issue 87, 2018
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Oxidative three-component 1,2-alkylarylation of alkenes with alkyl nitriles and N-heteroarenes

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Abstract

An indium-promoted intermolecular oxidative 1,2-alkylarylation of alkenes with alkyl nitriles and N-heteroarenes enabled by C(sp3)–H/C(sp2)–H functionalization is presented. This oxidative radical strategy allows the formation of two new C–C bonds through transformations of two different C–H bonds across the alkenes in a controlled single-step manner, and offers a general, highly atom-economic route for the production of new functionalized N-heteroarenes, including indoles, pyrrolo[2,3-b]pyridine, pyrrolo[3,2,1-ij]quinolone and pyrroles.

Graphical abstract: Oxidative three-component 1,2-alkylarylation of alkenes with alkyl nitriles and N-heteroarenes

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Publication details

The article was received on 09 Aug 2018, accepted on 08 Oct 2018 and first published on 08 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06509H
Citation: Chem. Commun., 2018,54, 12345-12348
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    Oxidative three-component 1,2-alkylarylation of alkenes with alkyl nitriles and N-heteroarenes

    X. Ouyang, M. Hu, R. Song and J. Li, Chem. Commun., 2018, 54, 12345
    DOI: 10.1039/C8CC06509H

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