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Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

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Abstract

MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.

Graphical abstract: Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

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Publication details

The article was received on 09 Aug 2018, accepted on 28 Sep 2018 and first published on 09 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06480F
Citation: Chem. Commun., 2018, Advance Article
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    Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

    M. Uno, T. Watanabe-Nakayama, H. Konno, K. Akagi, N. Tsutsumi, T. Fukao, M. Shirakawa, H. Ohnishi and H. Tochio, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06480F

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