Issue 87, 2018
From the journal:

Chemical Communications

Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88†

Masatoshi Uno, ORCID logo ab   Takahiro Watanabe-Nakayama,c   Hiroki Konno,c   Ken-ichi Akagi,d   Naotaka Tsutsumi, ORCID logo ab   Toshiyuki Fukao,e   Masahiro Shirakawa,b   Hidenori Ohnishi*e  and  Hidehito Tochio ORCID logo *a  

* Corresponding authors

a Department of Biophysics, Kyoto University, Kyoto, Japan
E-mail: tochio@mb.biophys.kyoto-u.ac.jp

b Department of Molecular Engineering, Kyoto University, Kyoto, Japan

c Nano Life Science Institute (WPI NanoLSI), Kanazawa University, Kanazawa, Japan

d NIBIOHN, Section of Laboratory Equipment, Osaka, Japan

e Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
E-mail: ohnishih@gifu-u.ac.jp

Abstract

MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.

Graphical abstract: Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

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Article information

DOI
https://doi.org/10.1039/C8CC06480F
Article type
Communication
Submitted
09 Aug 2018
Accepted
28 Sep 2018
First published
09 Oct 2018

Chem. Commun., 2018,54, 12318-12321

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Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

M. Uno, T. Watanabe-Nakayama, H. Konno, K. Akagi, N. Tsutsumi, T. Fukao, M. Shirakawa, H. Ohnishi and H. Tochio, Chem. Commun., 2018, 54, 12318 DOI: 10.1039/C8CC06480F

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