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Issue 79, 2018
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A new C,N-cyclometalated osmium(II) arene anticancer scaffold with a handle for functionalization and antioxidative properties

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Abstract

A series of six osmium(II) complexes of the type [(η6-p-cymene)Os(C^N)X] (X = chlorido or acetato) containing benzimidazole C^N ligands with an ester group as a handle for further functionalization have been synthesized. They exhibit IC50 values in the low micromolar range in a panel of cisplatin (CDDP)-resistant cancer cells (approximately 10× more cytotoxic than CDDP in MCF-7), decrease the levels of intracellular ROS and reduce the NAD+ coenzyme, and inhibit tubulin polymerization. This discovery could open the door to a new large family of osmium(II)-based bioconjugates with diverse modes of action.

Graphical abstract: A new C,N-cyclometalated osmium(ii) arene anticancer scaffold with a handle for functionalization and antioxidative properties

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Publication details

The article was received on 07 Aug 2018, accepted on 04 Sep 2018 and first published on 04 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06427J
Citation: Chem. Commun., 2018,54, 11120-11123
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    A new C,N-cyclometalated osmium(II) arene anticancer scaffold with a handle for functionalization and antioxidative properties

    E. Ortega, J. G. Yellol, M. Rothemund, F. J. Ballester, V. Rodríguez, G. Yellol, C. Janiak, R. Schobert and J. Ruiz, Chem. Commun., 2018, 54, 11120
    DOI: 10.1039/C8CC06427J

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