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Issue 84, 2018
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Arylation of benzyl amines with aromatic nitriles

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In the past years, the activations of aromatic nitriles for radical arylations under photoirradiation have been developed. We here report the first example of radical arylations using aromatic nitriles without the assistance of photoirradiation. Importantly, with this method, the direct arylation of C(sp3)–H in benzyl amines provided a practical method for the synthesis of diarylmethylamines without the use of precious transition metal catalysts.

Graphical abstract: Arylation of benzyl amines with aromatic nitriles

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The article was received on 06 Aug 2018, accepted on 24 Sep 2018 and first published on 25 Sep 2018

Article type: Communication
DOI: 10.1039/C8CC06408C
Citation: Chem. Commun., 2018,54, 11881-11884

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    Arylation of benzyl amines with aromatic nitriles

    Y. Lei, J. Yang, R. Qi, S. Wang, R. Wang and Z. Xu, Chem. Commun., 2018, 54, 11881
    DOI: 10.1039/C8CC06408C

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