Arylation of benzyl amines with aromatic nitriles

Yingjie Lei; Ju Yang; Rupeng Qi; Shan Wang; Rui Wang; Zhaoqing Xu

doi:10.1039/C8CC06408C

Arylation of benzyl amines with aromatic nitriles

Yingjie Lei,^a Ju Yang,^a Rupeng Qi,^a Shan Wang,^a Rui Wang*^a and Zhaoqing Xu*^a

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* Corresponding authors

^a Key Laboratory of Preclinical Study for New Drugs of Gansu Province, The Institute of Pharmacology, School of Basic Medical Sciences, Lanzhou University, 199 West Donggang Road, Lanzhou 730000, China
E-mail: wangrui@lzu.edu.cn, zqxu@lzu.edu.cn

Abstract

In the past years, the activations of aromatic nitriles for radical arylations under photoirradiation have been developed. We here report the first example of radical arylations using aromatic nitriles without the assistance of photoirradiation. Importantly, with this method, the direct arylation of C(sp³)–H in benzyl amines provided a practical method for the synthesis of diarylmethylamines without the use of precious transition metal catalysts.

Supplementary files

Publication details

The article was received on 06 Aug 2018, accepted on 24 Sep 2018 and first published on 25 Sep 2018

Article type: Communication

DOI: 10.1039/C8CC06408C

Citation: Chem. Commun., 2018,54, 11881-11884

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Arylation of benzyl amines with aromatic nitriles

Y. Lei, J. Yang, R. Qi, S. Wang, R. Wang and Z. Xu, Chem. Commun., 2018, 54, 11881
DOI: 10.1039/C8CC06408C
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Chemical Communications

Arylation of benzyl amines with aromatic nitriles

Abstract

Supplementary files

Publication details

Arylation of benzyl amines with aromatic nitriles

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