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Issue 87, 2018
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Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols

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Abstract

Nickel-catalyzed, highly diastereoselective annulations between activated allenes and 2-acetylarylboronic acid or 2-formylarylboronic acids are reported. No ligand for nickel is required, and the reactions proceed efficiently at room temperature to give a broad range of substituted 3-methyleneindan-1-ols. Preliminary results of an enantioselective variant are also described.

Graphical abstract: Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols

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Publication details

The article was received on 06 Aug 2018, accepted on 10 Oct 2018 and first published on 11 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06388E
Citation: Chem. Commun., 2018,54, 12389-12392
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    Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols

    H. Panchal, C. Clarke, C. Bell, S. N. Karad, W. Lewis and H. W. Lam, Chem. Commun., 2018, 54, 12389
    DOI: 10.1039/C8CC06388E

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