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Issue 87, 2018
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Nickel-catalysed alkylation of C(sp3)–H bonds with alcohols: direct access to functionalised N-heteroaromatics

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Abstract

The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr2/L1 system enables access to a series of C(sp3)-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for α-alkylation.

Graphical abstract: Nickel-catalysed alkylation of C(sp3)–H bonds with alcohols: direct access to functionalised N-heteroaromatics

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Article information


Submitted
04 Aug 2018
Accepted
28 Sep 2018
First published
28 Sep 2018

Chem. Commun., 2018,54, 12369-12372
Article type
Communication

Nickel-catalysed alkylation of C(sp3)–H bonds with alcohols: direct access to functionalised N-heteroaromatics

M. Vellakkaran, J. Das, S. Bera and D. Banerjee, Chem. Commun., 2018, 54, 12369
DOI: 10.1039/C8CC06370B

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