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Nickel-Catalysed Alkylation of C(sp3)-H Bond with Alcohols: Direct Access to Functionalised N-Heteroaromatics

Abstract

The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. Use of an earth-abundant and nonprecious NiBr2/L1 system enables to access a series of C(sp3)-alkylated N-heteroaromatics. Mechanistic studies established the participation of hydrogen-borrowing strategy for α-alkylation.

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Publication details

The article was received on 04 Aug 2018, accepted on 28 Sep 2018 and first published on 28 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06370B
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Nickel-Catalysed Alkylation of C(sp3)-H Bond with Alcohols: Direct Access to Functionalised N-Heteroaromatics

    D. Banerjee, M. Vellakkaran, J. Das and S. Bera, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC06370B

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