Jump to main content
Jump to site search


Transition-metal-free multinitrogenation of amides by C–C bond cleavage: a new approach to tetrazoles

Author affiliations

Abstract

A metal-free brand-new one-pot multinitrogenation of amides for the chemo- and regioselective synthesis of 1,5-disubstituted tetrazoles has been developed. By means of electrophilic amide activation, and further C–C bond cleavage and rearrangement, a diverse set of functionalized 1,5-DST derivatives were selectively constructed under mild conditions. As showcased in the mechanisms, the chemoselectivity is easily switched by the selection of the starting materials in the reaction.

Graphical abstract: Transition-metal-free multinitrogenation of amides by C–C bond cleavage: a new approach to tetrazoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Aug 2018, accepted on 10 Sep 2018 and first published on 11 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06324A
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    Transition-metal-free multinitrogenation of amides by C–C bond cleavage: a new approach to tetrazoles

    L. Li, Z. Niu, Y. Li and Y. Liang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06324A

Search articles by author

Spotlight

Advertisements