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Issue 76, 2018
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A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial vaginosis

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Abstract

We report a turn-on tetravalent sialic acid-coated tetraphenylethene luminogen (TPE4S) with excellent hydrophilicity, good stability, high sensitivity and unique selectivity towards sialidases, and the maximum fluorescence enhancement was ∼40 fold. More importantly, TPE4S was successfully utilized for the screening of sialidase inhibitors and diagnosis of bacterial vaginosis.

Graphical abstract: A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial vaginosis

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Publication details

The article was received on 02 Aug 2018, accepted on 28 Aug 2018 and first published on 28 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC06300A
Citation: Chem. Commun., 2018,54, 10691-10694
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    A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial vaginosis

    G. Liu, B. Wang, Y. Zhang, G. Xing, X. Yang and S. Wang, Chem. Commun., 2018, 54, 10691
    DOI: 10.1039/C8CC06300A

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