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Issue 80, 2018
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Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(II) complexes

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Abstract

We present a thiophene-based terpyridine Zn(II) complex (namely LC) which could specifically target live cell mitochondria via binding with mitochondrial DNA (mtDNA). Due to its high biocompatibility, red emission and photo-stability, mtDNA distribution within mitochondrial cristae and inner matrix in living cells was successfully visualized using stimulated emission depletion (STED) nanoscopy with unprecedented resolution.

Graphical abstract: Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(ii) complexes

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Publication details

The article was received on 01 Aug 2018, accepted on 12 Sep 2018 and first published on 13 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06276E
Citation: Chem. Commun., 2018,54, 11288-11291
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    Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(II) complexes

    Y. Shen, T. Shao, B. Fang, W. Du, M. Zhang, J. Liu, T. Liu, X. Tian, Q. Zhang, A. Wang, J. Yang, J. Wu and Y. Tian, Chem. Commun., 2018, 54, 11288
    DOI: 10.1039/C8CC06276E

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