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Issue 80, 2018
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Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(ii) complexes

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Abstract

We present a thiophene-based terpyridine Zn(II) complex (namely LC) which could specifically target live cell mitochondria via binding with mitochondrial DNA (mtDNA). Due to its high biocompatibility, red emission and photo-stability, mtDNA distribution within mitochondrial cristae and inner matrix in living cells was successfully visualized using stimulated emission depletion (STED) nanoscopy with unprecedented resolution.

Graphical abstract: Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(ii) complexes

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Article information


Submitted
01 Aug 2018
Accepted
12 Sep 2018
First published
13 Sep 2018

Chem. Commun., 2018,54, 11288-11291
Article type
Communication

Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(II) complexes

Y. Shen, T. Shao, B. Fang, W. Du, M. Zhang, J. Liu, T. Liu, X. Tian, Q. Zhang, A. Wang, J. Yang, J. Wu and Y. Tian, Chem. Commun., 2018, 54, 11288
DOI: 10.1039/C8CC06276E

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