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Issue 91, 2018
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Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds

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Abstract

Celastrol is one of the most studied natural products. Our studies show for the first time that celastrol can bind to its target protein via specific noncovalent interactions that position celastrol next to the thiol group of the reactive cysteine for reversible covalent bond formation. Such specific noncovalent interactions confer celastrol binding specificity and demonstrate the feasibility of improving the efficacy and selectivity of celastrol for therapeutic applications.

Graphical abstract: Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds

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Publication details

The article was received on 28 Jul 2018, accepted on 18 Oct 2018 and first published on 18 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06140H
Citation: Chem. Commun., 2018,54, 12871-12874
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    Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds

    D. Zhang, Z. Chen, C. Hu, S. Yan, Z. Li, B. Lian, Y. Xu, R. Ding, Z. Zeng, X. Zhang and Y. Su, Chem. Commun., 2018, 54, 12871
    DOI: 10.1039/C8CC06140H

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