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Issue 78, 2018
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Copper-catalyzed amination of an α-C(sp3)–H bond in inactivated ethers to synthesize α-aminonitriles

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Abstract

A copper-catalyzed functionalization of inert cyclic ethers was developed to provide α-aminonitriles via a cascade oxidation/amination/ring-opening/cyanation reaction. A series of highly versatile α-aminonitriles were obtained from primary or secondary anilines, and heterocyclic and aliphatic amines with high yields. This process features excellent functional group tolerance, a broad substrate scope, and high activity under ambient conditions.

Graphical abstract: Copper-catalyzed amination of an α-C(sp3)–H bond in inactivated ethers to synthesize α-aminonitriles

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Publication details

The article was received on 27 Jul 2018, accepted on 06 Sep 2018 and first published on 06 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06111D
Citation: Chem. Commun., 2018,54, 11033-11036
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    Copper-catalyzed amination of an α-C(sp3)–H bond in inactivated ethers to synthesize α-aminonitriles

    Z. Yuan, C. Zhu, Z. Ma and C. Xia, Chem. Commun., 2018, 54, 11033
    DOI: 10.1039/C8CC06111D

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