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Issue 76, 2018
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A halogen bond-donor amino acid for organocatalysis in water

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Abstract

Herein we report a halogen bond-donor amino acid, 4-iodotetrafluorophenylalanine, which behaves as a catalyst for the aqueous synthesis of bis-(heterocyclic)methanes. We also provide experimental evidence that halogen bonding is a plausible explanation for the observed catalytic effect.

Graphical abstract: A halogen bond-donor amino acid for organocatalysis in water

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Publication details

The article was received on 24 Jul 2018, accepted on 30 Aug 2018 and first published on 30 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC06010J
Chem. Commun., 2018,54, 10718-10721

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    A halogen bond-donor amino acid for organocatalysis in water

    G. Bergamaschi, L. Lascialfari, A. Pizzi, M. I. Martinez Espinoza, N. Demitri, A. Milani, A. Gori and P. Metrangolo, Chem. Commun., 2018, 54, 10718
    DOI: 10.1039/C8CC06010J

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