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Issue 68, 2018
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Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

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Abstract

We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.

Graphical abstract: Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

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Publication details

The article was received on 15 Jul 2018, accepted on 20 Jul 2018 and first published on 23 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC05721D
Citation: Chem. Commun., 2018,54, 9410-9413
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    Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

    H. B. D. Thai, F. Levi-Acobas, S. Yum, G. Jang, M. Hollenstein and D. Ahn, Chem. Commun., 2018, 54, 9410
    DOI: 10.1039/C8CC05721D

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