A matrix metalloproteinase (MMP) targeted tetrapeptide vesicle has been designed and developed, which strongly binds at a MMP9 enzymatic site. Interestingly, it has a propensity to encapsulate and deliver the doxorubicin drug specifically to the cancer cell, induces superior apoptotic death, and inhibits the metastatic cancer cell migration and growth of multicellular 3D spheroids.
D. Bhunia, K. Pradhan, G. Das, S. Ghosh, P. Mondal and S. Ghosh, Chem. Commun., 2018, 54, 9309 DOI: 10.1039/C8CC05687K
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