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Issue 70, 2018
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A supramolecular hybrid material constructed from pillar[6]arene-based host–guest complexation and ZIF-8 for targeted drug delivery

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Abstract

A novel supramolecular hybrid material ZIF-8@DOX@WP6@G constructed from the host–guest complexation between carboxylated pillar[6]arene (WP6) and a galactose derivative (G), and doxorubicin (DOX)-loaded ZIF-8 has been synthesized for targeted drug delivery. The results showed that ZIF-8@DOX@WP6@G not only maintained the pH-sensitive drug release properties of ZIF-8 but also exhibited excellent water dispersibility and selective toxicity for hepatoma cancer cells due to the assembly of WP6 and G. The strategy used in this study opens up a new avenue for constructing multifunctional supramolecular hybrid materials for therapeutic applications in cancer treatment.

Graphical abstract: A supramolecular hybrid material constructed from pillar[6]arene-based host–guest complexation and ZIF-8 for targeted drug delivery

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Publication details

The article was received on 13 Jul 2018, accepted on 06 Aug 2018 and first published on 06 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05665J
Citation: Chem. Commun., 2018,54, 9817-9820
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    A supramolecular hybrid material constructed from pillar[6]arene-based host–guest complexation and ZIF-8 for targeted drug delivery

    K. Yang, K. Yang, S. Chao, J. Wen, Y. Pei and Z. Pei, Chem. Commun., 2018, 54, 9817
    DOI: 10.1039/C8CC05665J

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