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Issue 83, 2018
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Noncovalent spin-labeling of RNA: the aptamer approach

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Abstract

In the first example of site-directed spin-labeling of unmodified RNA, a pyrrolidine-nitroxide derivative of tetramethylrosamine (TMR) was shown to bind with high affinity to the malachite green (MG) aptamer, as determined by continuous-wave (CW) electron paramagnetic resonance (EPR), pulsed electron–electron double resonance (PELDOR) and fluorescence spectroscopies.

Graphical abstract: Noncovalent spin-labeling of RNA: the aptamer approach

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Publication details

The article was received on 11 Jul 2018, accepted on 24 Sep 2018 and first published on 02 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC05597A
Citation: Chem. Commun., 2018,54, 11749-11752

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    Noncovalent spin-labeling of RNA: the aptamer approach

    S. Saha, T. Hetzke, T. F. Prisner and S. Th. Sigurdsson, Chem. Commun., 2018, 54, 11749
    DOI: 10.1039/C8CC05597A

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