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Issue 84, 2018
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CDy14: a novel biofilm probe targeting exopolysaccharide Psl

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Abstract

Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.

Graphical abstract: CDy14: a novel biofilm probe targeting exopolysaccharide Psl

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Article information


Submitted
10 Jul 2018
Accepted
03 Sep 2018
First published
04 Sep 2018

Chem. Commun., 2018,54, 11865-11868
Article type
Communication

CDy14: a novel biofilm probe targeting exopolysaccharide Psl

H. Kwon, J. Kim, J. Y. Lee, J. K. H. Yam, L. D. Hultqvist, W. Xu, M. Rybtke, T. Tolker-Nielsen, J. Kim, N. Kang, L. Yang, S. Park, M. Givskov and Y. Chang, Chem. Commun., 2018, 54, 11865
DOI: 10.1039/C8CC05544K

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