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Issue 70, 2018
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Turning off Bacillus cereus quorum sensing system with peptidic analogs

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Abstract

We explored quenching of the PlcR–PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

Graphical abstract: Turning off Bacillus cereus quorum sensing system with peptidic analogs

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Supplementary files

Article information


Submitted
09 Jul 2018
Accepted
01 Aug 2018
First published
14 Aug 2018

Chem. Commun., 2018,54, 9777-9780
Article type
Communication

Turning off Bacillus cereus quorum sensing system with peptidic analogs

A. Yehuda, L. Slamti, R. Bochnik-Tamir, E. Malach, D. Lereclus and Z. Hayouka, Chem. Commun., 2018, 54, 9777
DOI: 10.1039/C8CC05496G

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