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Issue 63, 2018
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The CF3-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation

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Abstract

A trifluoromethyl analogue of diethylaminosulfur trifluoride (CF3-DAST)-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones, lactams, and lactones that provides cyclic α-trifluoromethylthioketones, lactams, and lactones is reported. To the best of our knowledge, this method represents the first example of the trifluoromethylthiolation of lactams. A corresponding deacylative pentafluorophenylthiolation using a pentafluorophenyl analogue of diethylaminosulfur trifluoride (C6F5-DAST) was also attempted.

Graphical abstract: The CF3-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation

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Publication details

The article was received on 05 Jul 2018, accepted on 12 Jul 2018 and first published on 13 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC05409F
Citation: Chem. Commun., 2018,54, 8761-8764
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    The CF3-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation

    I. Saidalimu, T. Yoshioka, Y. Liang, E. Tokunaga and N. Shibata, Chem. Commun., 2018, 54, 8761
    DOI: 10.1039/C8CC05409F

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