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Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin DNA conjugates

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Abstract

We describe an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin functionalised ssDNA probes. The sensitivity at the attomolar concentration level arises from an increased density of redox labels on the electrode surface compared to sensors without NP modification. The electrode detects as few as 23 DNA molecules, approaching single molecule detection.

Graphical abstract: Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin DNA conjugates

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Publication details

The article was received on 04 Jul 2018, accepted on 03 Aug 2018 and first published on 06 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05362F
Citation: Chem. Commun., 2018, Advance Article
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    Approaching single DNA molecule detection with an ultrasensitive electrochemical genosensor based on gold nanoparticles and cobalt-porphyrin DNA conjugates

    B. Kaur, K. Malecka, D. A. Cristaldi, C. S. Chay, I. Mames, H. Radecka, J. Radecki and E. Stulz, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05362F

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