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Issue 75, 2018
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A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

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Abstract

The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.

Graphical abstract: A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

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Article information


Submitted
01 Jul 2018
Accepted
24 Aug 2018
First published
27 Aug 2018

Chem. Commun., 2018,54, 10630-10633
Article type
Communication

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

L. A. Ho, J. L. Winogrodzki, A. W. Debowski, Z. Madden, D. J. Vocadlo, B. L. Mark and K. A. Stubbs, Chem. Commun., 2018, 54, 10630
DOI: 10.1039/C8CC05281F

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