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Issue 64, 2018
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Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

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Abstract

An efficient protocol for oximinotrifluoromethylation of unactivated alkenes was developed via trifluoromethyl radical-induced intramolecular remote oximino migration under mild reaction conditions, providing a wide range of β-trifluoromethylated oximes. Other fluoroalkyl radicals were also applicable for this transformation. This method provided access to synthetically challenging medium-sized ring scaffolds and the 6,7,5-fused lactam skeleton.

Graphical abstract: Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

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Publication details

The article was received on 28 Jun 2018, accepted on 17 Jul 2018 and first published on 18 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC05186K
Chem. Commun., 2018,54, 8885-8888

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    Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

    N. Wang, J. Wang, Y. Guo, L. Li, Y. Sun, Z. Li, H. Zhang, Z. Guo, Z. Li and X. Liu, Chem. Commun., 2018, 54, 8885
    DOI: 10.1039/C8CC05186K

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