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Issue 72, 2018
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Reductive cyclisations of amidines involving aminal radicals

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Abstract

Amidines bearing simple alkenes undergo aminal radical cyclisation upon treatment with SmI2. The mild, reductive electron transfer process delivers medicinally-relevant, polycyclic quinazolinone derivatives in good to excellent yield and typically with complete diastereocontrol.

Graphical abstract: Reductive cyclisations of amidines involving aminal radicals

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Article information


Submitted
28 Jun 2018
Accepted
14 Aug 2018
First published
15 Aug 2018

Chem. Commun., 2018,54, 10160-10163
Article type
Communication

Reductive cyclisations of amidines involving aminal radicals

H. Huang, R. W. Adams and D. J. Procter, Chem. Commun., 2018, 54, 10160
DOI: 10.1039/C8CC05178J

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