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Issue 70, 2018
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Enzyme-triggered self-assembly of gold nanoparticles for enhanced retention effects and photothermal therapy of prostate cancer

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Abstract

A peptide-modified gold nanoparticle was developed for tumour-targeted therapy. Triggered by alkaline phosphatase, the CREKA-YPFFK(Nph) peptide can self-assemble and further result in accumulation of gold nanoparticles in tumour cells. The large-sized gold nanoparticle aggregates cannot escape from the tumour tissue, therefore realizing the goal of tumour-specific targeting, enhanced retention and photothermal effects.

Graphical abstract: Enzyme-triggered self-assembly of gold nanoparticles for enhanced retention effects and photothermal therapy of prostate cancer

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Publication details

The article was received on 27 Jun 2018, accepted on 02 Aug 2018 and first published on 02 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05136D
Citation: Chem. Commun., 2018,54, 9841-9844
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    Enzyme-triggered self-assembly of gold nanoparticles for enhanced retention effects and photothermal therapy of prostate cancer

    S. Yang, D. Yao, Y. Wang, W. Yang, B. Zhang and D. Wang, Chem. Commun., 2018, 54, 9841
    DOI: 10.1039/C8CC05136D

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