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Issue 72, 2018
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Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

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Abstract

Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with nM KD. The binding significantly reduced the cellular uptake of toxic tau oligomers and protected the cells from tau oligomer induced cytotoxicity.

Graphical abstract: Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

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Supplementary files

Article information


Submitted
25 Jun 2018
Accepted
13 Aug 2018
First published
14 Aug 2018

Chem. Commun., 2018,54, 10120-10123
Article type
Communication

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

P. Wang, F. Lo Cascio, J. Gao, R. Kayed and X. Huang, Chem. Commun., 2018, 54, 10120
DOI: 10.1039/C8CC05072D

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