Issue 69, 2018
From the journal:

Chemical Communications

Branch-PCR constructed TP53 gene nanovector for potential cancer therapy†

Longhuai Cheng, ORCID logo ‡a   Huiting Deng,‡b   Dejun Ma, ORCID logo b   Beibei Zhai,b   Qiangzhe Zhang,*b   Luyuan Li*b  and  Zhen Xi ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, National Pesticide Engineering Research Center (Tianjin), Collaborative Innovation Center of Chemical Science and Engineering, (Tianjin), College of Chemistry, Nankai University, Tianjin, China
E-mail: zhenxi@nankai.edu.cn
Tel: +86 22 23504782

b State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China
E-mail: liluyuan@nankai.edu.cn, zhangqiangzhe@nankai.edu.cn

Abstract

A novel and efficient branch PCR strategy has been used to construct a TP53 gene nanovector based on a pair of trimers as primers, which showed unique advantages compared to other existing systems for gene delivery and effective potential cancer therapy.

Graphical abstract: Branch-PCR constructed TP53 gene nanovector for potential cancer therapy

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Article information

DOI
https://doi.org/10.1039/C8CC05066J
Article type
Communication
Submitted
26 Jun 2018
Accepted
31 Jul 2018
First published
01 Aug 2018

Chem. Commun., 2018,54, 9687-9690

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Branch-PCR constructed TP53 gene nanovector for potential cancer therapy

L. Cheng, H. Deng, D. Ma, B. Zhai, Q. Zhang, L. Li and Z. Xi, Chem. Commun., 2018, 54, 9687 DOI: 10.1039/C8CC05066J

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