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Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation

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Abstract

We synthesized and characterized two novel sterol-anchored polyethylene glycols (PEG) as potential alternatives to conventional phosphatidylethanolamine-PEGs. Liposomes containing the dicholesterol anchored PEG at 5 mole percent exhibit canonical PEGgylated-liposome behaviors including retention of encapsulated small molecules, low serum protein adsorption, and reduced cellular uptake yet they do not exhibit long circulation.

Graphical abstract: Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation

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Publication details

The article was received on 22 Jun 2018, accepted on 21 Sep 2018 and first published on 05 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC05011B
Citation: Chem. Commun., 2018, Advance Article
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    Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation

    A. Dolor, P. Kierstead, Z. Dai and F. C. Szoka, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05011B

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