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Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells

Abstract

Magnetic poly(L-lactide) coarse microspheres were synthesized by emulsion method followed by chemical etching. Subsequently, anti-CD3 and anti-CD28 antibodies were attached to the microspheres via avidin-biotin amplification system as artificial antigen-presenting cells. The activation of T cells was enhanced significantly due to surface topographic structure and increased signal molecules amount.

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Publication details

The article was received on 21 Jun 2018, accepted on 12 Sep 2018 and first published on 14 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC04958K
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells

    T. zhang, M. Li, X. wang, Z. Zhou, W. Yuan and J. MA, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC04958K

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