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Issue 80, 2018
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Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells

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Abstract

Magnetic poly(L-lactide) coarse microspheres were synthesized via an emulsion method followed by chemical etching. Subsequently, anti-CD3 and anti-CD28 antibodies were attached to the microspheres via an avidin–biotin amplification system as artificial antigen-presenting cells. The activation of T cells was enhanced significantly due to the surface topographic structure and increased signal molecule amount.

Graphical abstract: Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells

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Publication details

The article was received on 21 Jun 2018, accepted on 12 Sep 2018 and first published on 14 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC04958K
Citation: Chem. Commun., 2018,54, 11356-11359
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    Facile synthesis of polylactide coarse microspheres as artificial antigen-presenting cells

    T. Zhang, M. Li, X. Wang, Z. Zhou, W. Yuan and J. Ma, Chem. Commun., 2018, 54, 11356
    DOI: 10.1039/C8CC04958K

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