Jump to main content
Jump to site search


Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis

Author affiliations

Abstract

The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99 : 1 d.r.).

Graphical abstract: Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Jun 2018, accepted on 07 Sep 2018 and first published on 11 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC04946G
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis

    Y. Tao and S. R. Gilbertson, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04946G

Search articles by author

Spotlight

Advertisements