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Issue 62, 2018
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A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

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Abstract

Aminoacyladenylates (5′-aa-AMPs) are key intermediates in peptide synthesis. Here we report analogs of 5′-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. Significantly, dipeptides were detected from the above reactions and their yields varied with different nucleosides through the formation of different aa-N-NMPs. This model provides both prebiotic peptides and the primordial version of the genetic code through reactions that occurred under potentially prebiotic conditions.

Graphical abstract: A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

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Publication details

The article was received on 14 Jun 2018, accepted on 06 Jul 2018 and first published on 07 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04767G
Citation: Chem. Commun., 2018,54, 8598-8601
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    A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

    J. Ying, S. Fu, X. Li, L. Feng, P. Xu, Y. Liu, X. Gao and Y. Zhao, Chem. Commun., 2018, 54, 8598
    DOI: 10.1039/C8CC04767G

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