Development of a novel inducer of protein–protein interactions based on aplyronine A

Abstract

An aplyronine A–swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein–protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.