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Site-specific one-pot triple click labeling for DNA and RNA

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Abstract

We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels–Alder reaction and strain-promoted and copper catalyzed click reactions sequentially. Our methodology can be applied to long and short nucleic acids alike, and could have broader potential for labeling other (bio-)molecules.

Graphical abstract: Site-specific one-pot triple click labeling for DNA and RNA

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Publication details

The article was received on 06 Jun 2018, accepted on 26 Sep 2018 and first published on 26 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC04520H
Citation: Chem. Commun., 2018, Advance Article
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    Site-specific one-pot triple click labeling for DNA and RNA

    M. Winz, E. C. Linder, J. Becker and A. Jäschke, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC04520H

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